Oxacillin-resistant Staphylococcus aureus endophthalmitis after ganciclovir intraocular implant

PURPOSE: To describe a patient who developed oxacillin-resistant Staphylococcus aureus endophthalmitis after insertion of a ganciclovir intraocular implant. METHOD: Case report. RESULTS: A 42-year-old man with acquired immunodeficiency syndrome (AIDS) and a history of cytomegalovirus retinitis was a...

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Bibliographic Details
Published in:American journal of ophthalmology 2000-04, Vol.129 (4), p.554-555
Main Authors: Williamson, John C, Virata, Steven R, Raasch, Ralph H, Kylstra, Jan A
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - drug therapy
Bacterial diseases
Bacterial diseases of the eye and orbit
Biological and medical sciences
Cytomegalovirus Retinitis - drug therapy
Drug Implants - adverse effects
Drug Therapy, Combination - therapeutic use
Endophthalmitis - microbiology
Endophthalmitis - therapy
Eye Infections, Bacterial - etiology
Eye Infections, Bacterial - therapy
Ganciclovir - administration & dosage
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Oxacillin - therapeutic use
Penicillin Resistance
Penicillins - pharmacology
Reoperation
Staphylococcal Infections - etiology
Staphylococcal Infections - therapy
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Vitreous Body - microbiology
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Summary:PURPOSE: To describe a patient who developed oxacillin-resistant Staphylococcus aureus endophthalmitis after insertion of a ganciclovir intraocular implant. METHOD: Case report. RESULTS: A 42-year-old man with acquired immunodeficiency syndrome (AIDS) and a history of cytomegalovirus retinitis was admitted with right-sided eye pain and decreased visual acuity 10 days after receiving a second ganciclovir intraocular implant in the right eye. A therapeutic vitrectomy, right eye, was performed on the day of admission. A vitreal tap produced frank pus and white, fluffy debris. Cultures of the vitreal fluid grew oxacillin-resistant S aureus, sensitive only to vancomycin, rifampin, and trimethoprim/sulfamethoxazole. The patient was successfully treated with removal of both ganciclovir implants in the right eye and a 4-week course of vancomycin and rifampin. However, the infection left the patient blind in the infected eye. CONCLUSION: Bacterial endophthalmitis is an infrequent but serious complication of the ganciclovir intraocular implant.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(99)00479-1