Designing experiments to optimise and validate the adsorptive stripping voltammetric determination of nimesulide

The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett–Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation a...

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Bibliographic Details
Published in:Analytica chimica acta 2000-05, Vol.413 (1), p.229-239
Main Authors: Furlanetto, S, Orlandini, S, Aldini, G, Gotti, R, Dreassi, E, Pinzauti, S
Format: Article
Language:English
Subjects:
Adsorptive stripping voltammetry
Dosage form
Experimental design
Nimesulide determination
Validation
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Summary:The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett–Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32×10 −9–3.85×10 −7 M and the dosage form mean recovery was 101.3% with RSD of 1.3% ( n=9).
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(00)00735-2