Determination of thiamine, riboflavin and pyridoxine in pharmaceuticals by synchronous fluorescence spectrometry in organized media

Synchronous fluorescence possibilities for the determination of three water-soluble vitamins, thiamine, pyridoxine and riboflavin, in presence of bis-2-ethylhexysulfosuccinate sodium salt (AOT) micelles, were studied. Synchronous fluorescence was chosen due to the good analytical characteristics fou...

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Bibliographic Details
Published in:Analytica chimica acta 2001-05, Vol.434 (2), p.193-199
Main Authors: Garcı́a, L, Blázquez, S, San Andrés, M.P, Vera, S
Format: Article
Language:English
Subjects:
Analysis
AOT
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Room temperature fluorescence
Synchronous fluorescence
Water-soluble vitamins
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Summary:Synchronous fluorescence possibilities for the determination of three water-soluble vitamins, thiamine, pyridoxine and riboflavin, in presence of bis-2-ethylhexysulfosuccinate sodium salt (AOT) micelles, were studied. Synchronous fluorescence was chosen due to the good analytical characteristics found. Repeatability, expressed as %R.S.D. was smaller than 1.4, sensitivity calculated as the slope of the straight line was of the order of 10 10 l mol −1 cm −1 in all the cases and detection limits were 12 μg l −1 for thiamine, 10 μg l −1 for pyridoxine and 9 μg l −1 for riboflavin. Synchronous fluorescence was applied to carry out the analysis of the three vitamins in pharmaceuticals.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(01)00836-4