Determination of degradation products of nerve agents in human serum by solid phase extraction using molecularly imprinted polymer

Molecularly imprinted polymers (MIPs) for pinacolyl methylphosphonate, ethyl methylphosphonate and methane phosphonic acid were prepared. By taking the advantage of their cross selectivity, the MIPs could recognize not only the print molecule, but also the degradation products of the other nerve age...

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Bibliographic Details
Published in:Analytica chimica acta 2001-05, Vol.435 (1), p.121-127
Main Authors: Zi-Hui, Meng, Qin, Liu
Format: Article
Language:English
Subjects:
Biological and medical sciences
Capillary electrophoresis
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical warfare
Medical sciences
Molecular imprinting
Nerve agents
Solid phase extraction
Toxicology
Various organic compounds
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Summary:Molecularly imprinted polymers (MIPs) for pinacolyl methylphosphonate, ethyl methylphosphonate and methane phosphonic acid were prepared. By taking the advantage of their cross selectivity, the MIPs could recognize not only the print molecule, but also the degradation products of the other nerve agents. The absorbed degradation products could be quantitatively extracted using distilled water. The pinacolyl methylphosphonate-imprinted polymer was used as a solid phase extraction sorbent for all possible degradation products of nerve agents from human serum. Following the solid phase extraction procedure, accurate analysis for the degradation products was carried out using capillary electrophoresis directly. A detection limit of 0.1 μg/ml and an R.S.D. of 0.99, n=4) in the concentration range of 0.1–10 μg/ml was also obtained.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(01)00858-3