Interrelationship between fatty acid composition, lipid peroxidation and alpha-tocopherol consumption post-LDL-apheresis treatment evaluated by liquid chromatography and gas chromatography

The performance of regular low-density lipoprotein (LDL)-apheresis (LA) permits the achievement of lower levels of LDL-cholesterol (LDL-C) and the related apolipoprotein B-containing lipoproteins. Consequently, the application of LA may offer opportunities to study the influence of rapid changes of...

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Published in:Analytica chimica acta 2002-09, Vol.467 (1), p.125-132
Main Authors: Bláha, Vladimı́r, Solichová, Dagmar, Bláha, Milan, Hyšpler, Radomı́r, Havel, Eduard, Vyroubal, Pavel, Žd’ánský, Petr, Zadák, Zdeněk
Format: Article
Language:English
Subjects:
Atherosclerosis
Fatty acids
Hypercholesterolaemia
LDL-apheresis
Lipoprotein metabolism
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Summary:The performance of regular low-density lipoprotein (LDL)-apheresis (LA) permits the achievement of lower levels of LDL-cholesterol (LDL-C) and the related apolipoprotein B-containing lipoproteins. Consequently, the application of LA may offer opportunities to study the influence of rapid changes of lipid homeostasis upon particular atherogenic species. The purpose of the study was to analyze the interrelationship between fatty acid composition, lipid peroxidation, and alpha-tocopherol consumption post-immuno-LA (Sepharose 4b columns carrying an anti-apoprotein B antibody) in six hyperlipidemic patients (three men and three women, age 14–56 years) by liquid chromatography (LC) and gas chromatography (GC). Immediately after LA, we observed significantly decreased serum thiobarbituric acid-reactive substances (TBARS) and serum total Vitamin E ( P
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(02)00306-9