Application of probabilistic neural network in the clinical diagnosis of cancers based on clinical chemistry data

As a recently developed and powerful classification tool, probabilistic neural network was used to distinguish cancer patients from healthy persons according to the levels of nucleosides in human urine. Two datasets (containing 32 and 50 patterns, respectively) were investigated and the total consis...

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Bibliographic Details
Published in:Analytica chimica acta 2002-10, Vol.471 (1), p.77-86
Main Authors: Shan, Yichu, Zhao, Ruihuan, Xu, Guowang, Liebich, H.M, Zhang, Yukui
Format: Article
Language:English
Subjects:
Cancer
Classification
Nucleosides
Probabilistic neural network
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Summary:As a recently developed and powerful classification tool, probabilistic neural network was used to distinguish cancer patients from healthy persons according to the levels of nucleosides in human urine. Two datasets (containing 32 and 50 patterns, respectively) were investigated and the total consistency rate obtained was 100% for dataset 1 and 94% for dataset 2. To evaluate the performance of probabilistic neural network, linear discriminant analysis and learning vector quantization network were also applied to the classification problem. The results showed that the predictive ability of the probabilistic neural network is stronger than the others in this study. Moreover, the recognition rate for dataset 2 can achieve to 100% if combining these three methods together, which indicated the promising potential of clinical diagnosis by combining different methods.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(02)00924-8