Flow injection biamperometric determination of metronidazole with on-line photodegradation

The determination of metronidazole is performed in a flow injection assembly, provided with a 40 W low pressure mercury lamp and a home-made biamperometric flow-cell furnished with two platinum electrodes polarized at 100 mV. The sample solution after being irradiated is inserted into a pure water s...

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Bibliographic Details
Published in:Analytica chimica acta 1999-11, Vol.401 (1), p.229-236
Main Authors: Palomeque, M., Bautista, J.A.Garcı́a, Garcı́a Mateo, J.V., Calatayud, J.Martı́nez
Format: Article
Language:English
Subjects:
Analysis
Biamperometry
Biological and medical sciences
Flow injection analysis
General pharmacology
Medical sciences
Metronidazole
Pharmaceutical analysis
Pharmacology. Drug treatments
Photodegradation
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Summary:The determination of metronidazole is performed in a flow injection assembly, provided with a 40 W low pressure mercury lamp and a home-made biamperometric flow-cell furnished with two platinum electrodes polarized at 100 mV. The sample solution after being irradiated is inserted into a pure water stream. It then merges with an in situ mixed solution containing potassium iodide in sulphuric acid. The calibration graph was linear over the range 0.2–8.0 mg l −1 metronidazole; the 3 σ limit of detection was 0.008 mg l −1; the relative standard deviation was 0.6% (for 4 mg l −1 n = 13) and the sample throughput 50 h −1. The influence of foreign compounds is slight and the method is applied for the determination of metronidazole in pharmaceutical and galenic formulations.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(99)00479-1