CO-28: Flow-mediated dilatation (FMD) and endothelium-independent dilation (EID) in patients with multifocal fibromuscular dysplasia: a cross-sectional study

• Published in: Annales de cardiologie et d'angéiologie 2015-12, Vol.64, p.S13-S14
• Main Authors: Khettab, H., Lorthioir, A., Niarra, R., Chambon, Y., Jeunemaitre, X., Plouin, P.F., Laurent, S., Boutouyrie, P., Azizi, M.
• Format: Article
• Language: English
• ISSN: 0003-3928
• DOI: 10.1016/S0003-3928(16)30028-2

Fibromuscular dysplasia (FD) is a rare idiopathic, segmental, non-atherosclerotic non-inflammatory vascular disease, which occurs mostly in middle-aged patients and affects medium-sized arteries (renal and carotid arteries). We previously showed that FD is a general arterial disease with focal exacerbation of the trait. However, whether endothelial dysfunction may be involved in the pathophysiology of FD is unclear.Abstract CO-28 – TableFDEHHSAge, yrs52±952±952±9Women, n (%)43 (86%)43 (86%)42 (84%)Caucasian, n (%)38 (76%)38 (76%)42 (84%)Office SBP, mmHg125±15***121±12***113±10Antihypertensive drugs, n (range)2 (1-4)2 (1-4)0BA structureExternal diameter, mm3.91±0.72°4.19±0.694.00±0.64Distensibility, μm114±64115±57135±73IMT, μm319±79330±85303±97Internal diameter, mm3.34±0.643.56±0.663.47±0.57FMDBasal BA diameter; mm3.86±0.70*°4.17±0.634.02±0.65BA diameter (hand ischemia), mm3.91+0.71°°4.22+0.644.04+0.61BA diameter (hand hyperhemia), mm3.98±0.73*°4.29±0.634.16±0.62Change in BA diameter, %2.39 [0.31; 5.41]2.85 [–0.23; 6.15]2.67 [0.20; 5.73]Basal BA flow velocity, cm/s7.70±5.997.39±5.987.66±8.53BA flow velocity (ischemia), cm/s3.71±5.252.68±5.010.98±2.54BA flow velocity (hyperhemia) cm/s73±2969±2778±38EIDBasal BA diameter, mm3.92±0.69°°4.22±0.674.07±0.67Post-GTN BA diameter, mm4.43±0.69**°°4.82±0.614.74±0.71Change in BA diameter, %13.8 [7.9;19.0]15.3 [10.2; 18.9]18.4 [12.9;21.1]Post-GTN BA flow velocity, cm/s7.27±8.125.56±6.844.76±10.29*P