The effect of lead on the eruption rates of incisor teeth in rats

The effects of lead on the continuously erupting rat incisors under normo-, hyper- and hypofunctional conditions were investigated. Left lower incisors of 20 rats were rendered unimpeded (hypofunctional) by cutting them out of occlusion every 2 days; the right lower incisors of these rats were consi...

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Bibliographic Details
Published in:Archives of oral biology 2000-11, Vol.45 (11), p.951-955
Main Authors: Gerlach, R.F, Toledo, D.B, Novaes, P.D, Merzel, J, Line, S.R.P
Format: Article
Language:English
Subjects:
Animals
Body Weight
Dental Occlusion
Eruption
Follow-Up Studies
Incisor
Incisor - drug effects
Incisor - growth & development
Injections, Intraperitoneal
Lead
Lead - administration & dosage
Lead - blood
Lead - pharmacology
Male
Metals
Organometallic Compounds - administration & dosage
Organometallic Compounds - pharmacology
Periodontal Ligament - drug effects
Random Allocation
Rat
Rats
Rats, Wistar
Sodium Acetate - administration & dosage
Sodium Acetate - pharmacology
Statistics as Topic
Tooth Eruption - drug effects
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Summary:The effects of lead on the continuously erupting rat incisors under normo-, hyper- and hypofunctional conditions were investigated. Left lower incisors of 20 rats were rendered unimpeded (hypofunctional) by cutting them out of occlusion every 2 days; the right lower incisors of these rats were considered hyperfunctional. Measurements on normally growing teeth (normofunctional) were carried out in a group of ten rats whose teeth were not cut but only marked every 2 days. On day 7 of the experiment, half of the rats from these two groups were given a single intraperitoneal injection of lead acetate (40 mg/kg), and the other half received sodium acetate (22 mg/kg). Another group of 15 rats was used to obtain blood samples for lead determination 1 h, and 10, 20, and 30 days after lead administration. Animals were killed on day 32. Hypofunctional incisors from lead-treated rats erupted more slowly than control ones ( P
ISSN:0003-9969
1879-1506
DOI:10.1016/S0003-9969(00)00072-8