Peroxynitrite inhibits glutathione S-conjugate transport

Peroxynitrite was demonstrated to inhibit the active efflux of glutathione S-conjugates (2,4-dinitrophenyl- S-glutathione and bimane- S-glutathione) from human erythrocytes and the erythrocyte membrane ATPase activity stimulated by glutathione S-conjugates. As the multidrug resistance-associated pro...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1997-04, Vol.1325 (1), p.135-141
Main Authors: Soszyński, Mirosław, Bartosz, Grzegorz
Format: Article
Language:English
Subjects:
Biological Transport - drug effects
Bridged Bicyclo Compounds - metabolism
Dose-Response Relationship, Drug
Erythrocyte
Erythrocytes - metabolism
Glutathione - analogs & derivatives
Glutathione - metabolism
Glutathione S-conjugate
Humans
Membrane
Multidrug resistance-associated protein
Nitrates - pharmacology
Oxidative stress
Peroxynitrite
Transport
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Summary:Peroxynitrite was demonstrated to inhibit the active efflux of glutathione S-conjugates (2,4-dinitrophenyl- S-glutathione and bimane- S-glutathione) from human erythrocytes and the erythrocyte membrane ATPase activity stimulated by glutathione S-conjugates. As the multidrug resistance-associated protein (MRP) is responsible for the transport of glutathione S-conjugates in mammalian cells, these results point to the possibility of the effect of peroxynitrite on the MRP function.
ISSN:0005-2736
0006-3002
1879-2642
DOI:10.1016/S0005-2736(96)00251-9