The multidrug resistance protein family

The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2–6. In this review, we summarize what is known about the protein structure, the expression in tissues...

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Bibliographic Details
Published in:BBA - Biomembranes 1999-12, Vol.1461 (2), p.347-357
Main Authors: Borst, Piet, Evers, Raymond, Kool, Marcel, Wijnholds, Jan
Format: Article
Language:English
Subjects:
Animals
Anion Transport Proteins
ATP Binding Cassette Transporter, Subfamily B - genetics
ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics
ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
Carrier Proteins - genetics
Cell Line
Cell Membrane - metabolism
Cisplatin
Drug Resistance, Multiple - genetics
Glutathione - metabolism
Glutathione–drug conjugate pump
GSH
Humans
Membrane Transport Proteins
Models, Molecular
Multidrug resistance
Multidrug resistance protein
Multidrug Resistance-Associated Proteins
Phylogeny
Protein routing
Space life sciences
Terminology as Topic
Transfection
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Summary:The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2–6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.
ISSN:0005-2736
0006-3002
1879-2642
DOI:10.1016/S0005-2736(99)00167-4