The effect of clozapine on saliva flow rate: A pilot study

This study examined the effect of clozapine on saliva flow rate. Unstimulated whole saliva was collected from 9 patients taking clozapine (dose range = 50–400 mg/day) and from 8 controls who had never used clozapine. There was no significant difference between the average saliva flow rates in the tw...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1996-12, Vol.40 (11), p.1132-1134
Main Authors: Rabinowitz, Terry, Frankenburg, Frances R., Centorrino, Franca, Kando, Judith
Format: Article
Language:English
Subjects:
Antipsychotic Agents - adverse effects
Biological and medical sciences
Clozapine
Clozapine - adverse effects
deglutition
Drug toxicity and drugs side effects treatment
flow
Humans
Medical sciences
neuroleptic
Pharmacology. Drug treatments
Pilot Projects
saliva
Salivation - drug effects
sialorrhea
Sialorrhea - chemically induced
Toxicity: respiratory system, ent, stomatology
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Summary:This study examined the effect of clozapine on saliva flow rate. Unstimulated whole saliva was collected from 9 patients taking clozapine (dose range = 50–400 mg/day) and from 8 controls who had never used clozapine. There was no significant difference between the average saliva flow rates in the two groups ( p > .10), nor was there significant correlation between saliva flow rate and daily clozapine dose ( p > . 10). Alternative explanations for observations or complaints of excessive salivation, drooling, or a choking feeling while taking clozapine are proposed.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(96)89255-9