Facile nitroxide-mediated oxidations of d-glucose to d-glucaric acid

The oxidation of d-(+)-glucose to d-glucaric acid using the TEMPO-like nitroxide oxidation catalyst, 4-acetamido-2,2,6,6-tetramethyl-1-piperidinyloxy (4-acetamido-TEMPO) was carried out using several oxidizing agents and co-catalyst. The pH and temperature of the reactions were closely monitored to...

Full description

Saved in:
Bibliographic Details
Published in:Carbohydrate research 2001-11, Vol.336 (1), p.75-78
Main Authors: Merbouh, Nabyl, Francois Thaburet, Jean, Ibert, Mathias, Marsais, Francis, Bobbitt, James M
Format: Article
Language:English
Subjects:
Bleach
Cyclic N-Oxides - chemistry
Cyclic N-Oxides - pharmacology
Glucaric acid
Glucaric Acid - chemistry
Glucaric Acid - metabolism
Glucose - chemistry
Glucose - metabolism
Magnetic Resonance Spectroscopy
Nitrogen Oxides - chemistry
Nitrogen Oxides - pharmacology
Nitroxide
Oxidants - chemistry
Oxidation-Reduction
Primary alcohol oxidation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The oxidation of d-(+)-glucose to d-glucaric acid using the TEMPO-like nitroxide oxidation catalyst, 4-acetamido-2,2,6,6-tetramethyl-1-piperidinyloxy (4-acetamido-TEMPO) was carried out using several oxidizing agents and co-catalyst. The pH and temperature of the reactions were closely monitored to decrease degradations during the oxidation, and several isolation methods were explored. The oxidation of α- d-glucose to d-glucaric acid using a TEMPO-like nitroxide oxidation catalyst was carried out using several oxidizing agents and co-catalysts.
ISSN:0008-6215
1873-426X
DOI:10.1016/S0008-6215(01)00231-2