Photooxidation of 2 ′-deoxyguanosine 5 ′-monophosphate (dGMP) by flavin adenine dinucleotide (FAD) via electron transfer: a laser photolysis study

The study of the photosensitization mechanism of dGMP by flavin adenine dinucleotide (FAD) as sensitizer was carried out by time-resolved 308 and 248 nm laser flash photolysis. Direct evidence of electron transfer from dGMP to either triplet state of FAD ( 3 FAD *) or oxidized FAD radical (FAD + /FA...

Full description

Saved in:
Bibliographic Details
Published in:Chemical physics letters 2000-11, Vol.330 (3), p.389-396
Main Authors: Lu, Chang-Yuan, Yao, Si-De, Lin, Nian-Yun
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study of the photosensitization mechanism of dGMP by flavin adenine dinucleotide (FAD) as sensitizer was carried out by time-resolved 308 and 248 nm laser flash photolysis. Direct evidence of electron transfer from dGMP to either triplet state of FAD ( 3 FAD *) or oxidized FAD radical (FAD + /FAD(−H) ) was obtained. A comparison of nucleotide-free and -bound riboflavin suggests that the nucleotide environment does not markedly influence sensitizer reactivity.
ISSN:0009-2614
1873-4448
DOI:10.1016/S0009-2614(00)01092-7