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Vibrational analysis of carbonyl modes in different stages of light-induced cyclopyrimidine dimer repair reactions

The formation of cyclopyrimidine dimers is a DNA defect, which is repaired by the enzyme DNA photolyase in a light-induced reaction. Radical anions of the dimers have been suggested to occur as short-lived intermediates during repair. For their identification time-resolved Fourier-transform infrared...

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Bibliographic Details
Published in:Chemical physics letters 2001-11, Vol.349 (3), p.342-348
Main Authors: Schmitz, Matthias, Tavan, Paul, Nonella, Marco
Format: Article
Language:English
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Summary:The formation of cyclopyrimidine dimers is a DNA defect, which is repaired by the enzyme DNA photolyase in a light-induced reaction. Radical anions of the dimers have been suggested to occur as short-lived intermediates during repair. For their identification time-resolved Fourier-transform infrared (FTIR) spectroscopy will be a method of choice. To support and guide such spectroscopic studies we have calculated the vibrational spectra of various pyrimidine compounds using density functional methods. Our results suggest that the carbonyl vibrations of these molecules can serve as marker modes to identify and distinguish intermediates of the repair reaction.
ISSN:0009-2614
1873-4448
DOI:10.1016/S0009-2614(01)01221-0