A review of the epidemiology of 1,3-butadiene and chloroprene

Butadiene epidemiologic research has focused primarily on one cohort of workers in the North American styrene–butadiene rubber (SBR) industry and on the largest cohort of workers in the United States butadiene monomer industry. The most recent studies of these populations are characterized by carefu...

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Bibliographic Details
Published in:Chemico-biological interactions 2001-06, Vol.135, p.43-52
Main Authors: Acquavella, John F, Leonard, Robin C
Format: Article
Language:English
Subjects:
Butadienes - toxicity
Chloroprene
Chloroprene - toxicity
Cohort
Humans
Leukemia
Leukemia - chemically induced
Leukemia - epidemiology
Neoplasms - chemically induced
Neoplasms - epidemiology
North America - epidemiology
Occupational Diseases - chemically induced
Occupational Diseases - epidemiology
Occupational Exposure
Risk Assessment
Rubber
Styrene–butadiene rubber
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Summary:Butadiene epidemiologic research has focused primarily on one cohort of workers in the North American styrene–butadiene rubber (SBR) industry and on the largest cohort of workers in the United States butadiene monomer industry. The most recent studies of these populations are characterized by carefully enumerated study populations, extremely long and high quality mortality follow-up, accurate job categorizations, detailed exposure assessments, and comprehensive statistical analyses. Leukemia was clearly associated with increasing estimated butadiene exposure in the SBR study, but not in the monomer industry study. This has lead to hypotheses about exposure differences between these two industries and the presence of co-factors or confounders in the SBR industry. Research presented at this symposium should shed some light on these hypotheses. The chloroprene epidemiologic literature, on the other hand, is in an early stage of development. The existing studies are limited by poor exposure characterization, lack of control of potential confounding factors, incompleteness in cohort enumeration, short follow-up periods, and small numbers of cancer cases. The state of the science for chloroprene would be advanced by arranging more comprehensive studies than those that have been conducted to date.
ISSN:0009-2797
1872-7786
DOI:10.1016/S0009-2797(01)00169-7