The effects of delayed treatment with sialyl Lewis X against lipopolysaccharide-induced acute lung injury in rabbits

The therapeutic effects of a selectin inhibitor against lipopolysaccharide-induced acute lung injury were studied in rabbits by using sialyl Lewis X-oligosaccharide. Lipopolysaccharide-induced acute lung injury, as characterized by an impairment of pulmonary gas exchange, clinically resembles that o...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2000-03, Vol.392 (1), p.109-116
Main Authors: Hayashi, Hirotsugu, Koike, Haruhiko, Imanishi, Noriaki, Tojo, Shinichiro J
Format: Article
Language:English
Subjects:
Acute lung injury
Animals
Biological and medical sciences
Blood Pressure - drug effects
Capillary Permeability - drug effects
Lipopolysaccharide
Lipopolysaccharides - toxicity
Lung - drug effects
Lung - pathology
Male
Medical sciences
Neutrophils - drug effects
Neutrophils - physiology
Oligosaccharides - therapeutic use
Oxygen - blood
Pharmacology. Drug treatments
Pulmonary Gas Exchange - drug effects
Rabbits
Respiratory Distress Syndrome, Adult - drug therapy
Respiratory system
Selectin
Sialyl Lewis X
Time Factors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The therapeutic effects of a selectin inhibitor against lipopolysaccharide-induced acute lung injury were studied in rabbits by using sialyl Lewis X-oligosaccharide. Lipopolysaccharide-induced acute lung injury, as characterized by an impairment of pulmonary gas exchange, clinically resembles that of the acute respiratory distress syndrome. Delayed treatments with sialyl Lewis X-oligosaccharide (55 mg kg −1 i.v. bolus injection 0.5, 1 or 2 h after lipopolysaccharide administration+36 mg kg −1 h −1 i.v. infusion for 5.5, 5 or 4 h, respectively) prevented the lipopolysaccharide-induced impairments in pulmonary gas exchange, as well as the accumulation of polymorphonuclear leukocytes in the lung tissue. In contrast, this agent had no significant effects on lipopolysaccharide-induced systemic hypotension, the decrease in the number of circulating white blood cells and platelets or the decline in blood pH. This is the first demonstration that sialyl Lewis X-oligosaccharide is effective against the impairments in pulmonary gas exchange even if administered 0.5, 1 or 2 h following the lipopolysaccharide injection.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(00)00099-6