Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain

We examined the effects of nicotine exposure during pregnancy on serotonin transporter (SERT) expression in the brain. Nicotine (6 mg/kg/day) was administered to pregnant rats via subcutaneous injections or infusion pumps. Irrespective of the route of administration, nicotine increased SERT density...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2001-01, Vol.411 (3), p.279-282
Main Authors: Muneoka, Katsumasa, Ogawa, Tetsuo, Kamei, Kenji, Mimura, Yuichi, Kato, Hitomi, Takigawa, Morikuni
Format: Article
Language:English
Subjects:
5-HT (5-hydroxytryptamine, serotonin) transporter
Animals
Biological and medical sciences
Brain Chemistry - drug effects
Carrier Proteins - metabolism
Female
Infusion Pumps
Injections, Subcutaneous
Male
Medical sciences
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Nerve Tissue Proteins
Nicotine
Nicotine - administration & dosage
Nicotine - adverse effects
Nicotinic Agonists - administration & dosage
Nicotinic Agonists - adverse effects
Paroxetine
Paroxetine - metabolism
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Serotonin Plasma Membrane Transport Proteins
Serotonin Uptake Inhibitors - metabolism
Smoking
Tobacco, tobacco smoking
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We examined the effects of nicotine exposure during pregnancy on serotonin transporter (SERT) expression in the brain. Nicotine (6 mg/kg/day) was administered to pregnant rats via subcutaneous injections or infusion pumps. Irrespective of the route of administration, nicotine increased SERT density in the forebrain on postnatal day 22, but not in the other brain regions. Our results suggest that nicotine use by pregnant women might be an environmental factor influencing SERT expression in their children.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(00)00925-0