Relaxation induced by milrinone and rolipram in human penile arteries and veins

We studied the relaxant effects of milrinone, an inhibitor of phosphodiesterase 3, and rolipram, an inhibitor of phosphodiesterase 4, on contracted human penile dorsal artery and deep dorsal vein. Vascular rings from 12 multi-organ donors were suspended in organ baths for isometric recording of tens...

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Bibliographic Details
Published in:European journal of pharmacology 2002-05, Vol.444 (1), p.103-106
Main Authors: Segarra, Gloria, Medina, Pascual, Vila, José M., Martinez-León, Juan B., Domenech, Cristina, Prieto, Fernando, Lluch, Salvador
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
cAMP pathway
Child
Colforsin - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Genital system. Reproduction
Humans
Male
Medical sciences
Middle Aged
Milrinone
Milrinone - pharmacology
Muscle, Smooth, Vascular - drug effects
Penile artery
Penile vein
Penis - blood supply
Pharmacology. Drug treatments
Phosphodiesterase Inhibitors - pharmacology
Rolipram
Rolipram - pharmacology
Vasodilation - drug effects
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Summary:We studied the relaxant effects of milrinone, an inhibitor of phosphodiesterase 3, and rolipram, an inhibitor of phosphodiesterase 4, on contracted human penile dorsal artery and deep dorsal vein. Vascular rings from 12 multi-organ donors were suspended in organ baths for isometric recording of tension. Both milrinone and rolipram inhibited (100%) the contraction induced by noradrenaline and shifted the relaxation–response curves to the cAMP forming agents prostaglandin E 1 and forskolin to the left. The findings indicate that the cAMP pathway appears to be a main determinant of relaxation in human penile vessels.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(02)01621-7