Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: an effect reversed by thyroxine pretreatment

The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutam...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2003-01, Vol.460 (2), p.155-161
Main Authors: Pantos, Constantinos, Mourouzis, Iordanis, Tzeis, Stylianos, Moraitis, Panagiotis, Malliopoulou, Vassiliki, Cokkinos, Demosthenis D, Carageorgiou, Hariclia, Varonos, Dennis, Cokkinos, Dennis
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiotonic Agents - adverse effects
Cardiotonic Agents - pharmacology
Cardiovascular system
Dobutamine
Dobutamine - adverse effects
Dobutamine - pharmacology
Drug toxicity and drugs side effects treatment
Heart
Heart - drug effects
Heart - physiology
Heart - physiopathology
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
In Vitro Techniques
Inotrope
Ischaemia
Medical sciences
Miscellaneous
Myocardial Ischemia - complications
Myocardial Reperfusion Injury - etiology
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Pharmacology. Drug treatments
Propranolol - pharmacology
rat
Rats
Thyroxine
Thyroxine - pharmacology
Time Factors
Toxicity: cardiovascular system
Ventricular Function
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 μg/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 μg 100 g −1 body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(02)02927-8