σ Receptors: potential medications development target for anti-cocaine agents

The ability of cocaine to interact with σ receptors suggests a viable target for medications development. Recently, numerous novel compounds and antisense oligodeoxynucleotides targeting σ receptors have been synthesized and shown to prevent the behavioral toxicity and psychomotor stimulant effects...

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Bibliographic Details
Published in:European Journal of Pharmacology 2003-05, Vol.469 (1), p.1-12
Main Authors: Matsumoto, Rae R, Liu, Yun, Lerner, Megan, Howard, Eric W, Brackett, Daniel J
Format: Article
Language:English
Subjects:
Animals
Antisense
Biological and medical sciences
Cocaine
Cocaine - antagonists & inhibitors
Cocaine - metabolism
Conditioned place preference
Convulsion
Drug Delivery Systems - methods
Gene expression
Humans
Locomotor activity
Medical sciences
Microarray
Motor Activity - drug effects
Motor Activity - physiology
Oligonucleotides, Antisense - metabolism
Oligonucleotides, Antisense - pharmacology
Receptors, sigma - antagonists & inhibitors
Receptors, sigma - metabolism
Sensitization
Technology, Pharmaceutical - methods
σ Receptor
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Summary:The ability of cocaine to interact with σ receptors suggests a viable target for medications development. Recently, numerous novel compounds and antisense oligodeoxynucleotides targeting σ receptors have been synthesized and shown to prevent the behavioral toxicity and psychomotor stimulant effects of cocaine in animals. Protective doses of σ receptor antagonists have also been shown to prevent changes in gene expression that are induced by cocaine. Together, the studies provide insight and promising future directions for the development of potential medications for the treatment of cocaine addiction and overdose.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(03)01723-0