Respiratory effects of halothane and AMPA receptor antagonist synergy in rats

The influence of N-methyl- d-aspartate (NMDA) or α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor antagonists in combination with halothane anaesthesia on the respiratory system was investigated. Under 1.5% halothane anaesthesia, respiratory parameters including respiratory rate, min...

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Bibliographic Details
Published in:European journal of pharmacology 1998-01, Vol.342 (2), p.261-265
Main Authors: Shimazu, Yoshihiro, Umemura, Kazuo, Kawano, Ken-ichi, Hokamura, Kazuya, Kawazura, Hiroshi, Nakashima, Mitsuyoshi
Format: Article
Language:English
Subjects:
AMPA receptor antagonist
Anesthetics, Inhalation - pharmacology
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Blood Gas Analysis
Dizocilpine Maleate - pharmacology
Drug Synergism
Excitatory Amino Acid Antagonists - pharmacology
Glutamatergic system (aspartate and other excitatory aminoacids)
Halothane
Halothane - pharmacology
Hemodynamics - drug effects
Hemodynamics - physiology
In Vitro Techniques
Male
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
NMDA receptor antagonist
Pharmacology. Drug treatments
Quinoxalines - pharmacology
Rats
Rats, Wistar
Receptors, AMPA - antagonists & inhibitors
Respiration
Respiratory Mechanics - drug effects
Respiratory rate
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Summary:The influence of N-methyl- d-aspartate (NMDA) or α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor antagonists in combination with halothane anaesthesia on the respiratory system was investigated. Under 1.5% halothane anaesthesia, respiratory parameters including respiratory rate, minute volume, tidal volume, inspiratory and expiratory duration were measured before and after drug administration in rats. The AMPA receptor antagonists, 6-(1H-imidazol-1-yl)-7-nitro-2,3-(1H,4H)-quinoxalinedione hydrochloride, YM90K (5 and 10 mg/kg) and 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX, 15 mg/kg), which were administered intravenously for 30 min, significantly reduced the respiratory rate ( P
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(97)01484-2