The gene for hepatocyte nuclear factor (HNF)-4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver

The gene for a transcription factor hepatocyte nuclear factor-4α (HNF-4α) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4α gene in the liver. Stimulation of primary-cultured rat hepatocytes with dexamethasone or glucagon led to induction...

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Bibliographic Details
Published in:FEBS letters 2000-07, Vol.478 (1), p.141-146
Main Authors: Oyadomari, Seiichi, Matsuno, Fumihiko, Chowdhury, Shoaib, Kimura, Tatsuya, Iwase, Katsuro, Araki, Eiichi, Shichiri, Motoaki, Mori, Masataka, Takiguchi, Masaki
Format: Article
Language:English
Subjects:
Dexamethasone
Gene regulation
HNF, hepatocyte nuclear factor
Hormone
MODY, maturity-onset diabetes of the young
Primary hepatocyte
Streptozotocin
STZ, streptozotocin
Transcription factor
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Summary:The gene for a transcription factor hepatocyte nuclear factor-4α (HNF-4α) is responsible for maturity-onset diabetes of the young, type 1. We examined hormonal regulation of the HNF-4α gene in the liver. Stimulation of primary-cultured rat hepatocytes with dexamethasone or glucagon led to induction of HNF-4α mRNA, being antagonized by insulin. In the liver of streptozotocin-induced diabetic rat, mRNA and protein levels for HNF-4α were elevated, and were normalized by insulin treatment. Therefore, HNF-4α in the liver is likely to be involved in the regulation of glucose metabolism in response to these hormones.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(00)01840-8