Control of cell proliferation via transduction of sPLA 2-I activity and possible PPAR activation at the nuclear level

Pancreatic phospholipase A 2 (PLA 2-I) stimulates U III cells proliferation, a rat uterine cell line, after binding to membrane receptors, internalization and translocation. Here, we demonstrate that during these steps of internalization, PLA 2-I retains its hydrolytic activity and thus could exert...

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Bibliographic Details
Published in:FEBS letters 2001-02, Vol.490 (1), p.88-92
Main Authors: Specty, O., Pageaux, J.F., Dauça, M., Lagarde, M., Laugier, C., Fayard, J.M.
Format: Article
Language:English
Subjects:
Nuclear activity
Phospholipase A 2
Proliferation
Rat uterus
Signal transduction
Stromal cell
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Summary:Pancreatic phospholipase A 2 (PLA 2-I) stimulates U III cells proliferation, a rat uterine cell line, after binding to membrane receptors, internalization and translocation. Here, we demonstrate that during these steps of internalization, PLA 2-I retains its hydrolytic activity and thus could exert its proliferative effect via nuclear phospholipids hydrolysis. Since fatty acids and eicosanoids released by such activity are known to be ligands of PPAR, we study the expression of these nuclear receptors and demonstrate that, in the experimental conditions where PLA 2-I stimulates U III cells proliferation, PLA 2-I also regulates PPAR expression indicating a possible mechanism of its proliferative effect.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(00)02414-5