The endoproteolytic processing of αvβ5 integrin is involved in cytoskeleton remodelling and cell migration

We previously showed that the post-translational cleavage of αv subunit is essential for integrin-dependent signalling and cell adhesion. Here, we report that blocking αv subunit cleavage by expression of α1-PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelli...

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Bibliographic Details
Published in:FEBS letters 2004-01, Vol.557 (1), p.159-163
Main Authors: Berthet, Virginie, Rigot, Véronique, Nejjari, Mimoun, Marvaldi, Jacques, Luis, José
Format: Article
Language:English
Subjects:
Actin cytoskeleton
Colon carcinoma
DMEM, Dulbecco's modified Eagle's medium
ECM, extracellular matrix
Endoproteolytic cleavage
PMA, phorbol 12-myristate 13-acetate
Proprotein convertase
α1-PDX
αvβ5 integrin
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Summary:We previously showed that the post-translational cleavage of αv subunit is essential for integrin-dependent signalling and cell adhesion. Here, we report that blocking αv subunit cleavage by expression of α1-PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelling of the actin cytoskeleton upon cell attachment. These changes are associated with cell scattering and with a dramatic increase in cell migration to vitronectin. The αv subunit cleavage is thus essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(03)01467-4