The effect of some peptides from the hibernating brain on Ca 2+ current in cardiac cells and on the activity of septal neurons

The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca 2+ current were studied. TSKYR activated Ca 2+ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca 2+ current in both preparations. In isolated rat and grou...

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Bibliographic Details
Published in:FEBS letters 1997-07, Vol.411 (1), p.71-76
Main Authors: Kokoz, Yu.M., Zenchenko, K.I., Alekseev, A.E., Korystova, A.F., Lankina, D.A., Ziganshin, R.H., Mikhaleva, I.I., Ivanov, V.T.
Format: Article
Language:English
Subjects:
Ca 2+ current
Cardiocyte
Hibernation
Patch clamp
Peptide
Septal neuron
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Summary:The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca 2+ current were studied. TSKYR activated Ca 2+ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca 2+ current in both preparations. In isolated rat and ground squirrel cardiocytes, TSKYR had no effect on Ca 2+ current, and DY increased it. In brain slices of rat, DY blocked the activity of medial septal neurons. TSKYR increased activity of septal neurons at the initial phase, which was followed by decrease of neuronal activity.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(97)00607-8