Genomic structure and chromosomal location of the human TGFβ-receptor interacting protein-1 (TRIP-1) gene to 1p34.1

The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signa...

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Bibliographic Details
Published in:FEBS letters 1998-04, Vol.426 (2), p.279-282
Main Authors: Galli-Stauber, Claudia, Raho, Giovanna, Rossi, Daniela, Corona, Davide F.V, Pirola, Barbara, Bonaglia, Maria Clara, Zuffardi, Orsetta, Sorrentino, Vincenzo
Format: Article
Language:English
Subjects:
FISH
Fluorescence in situ hybridisation
TGFβ
TGFβ-receptor interacting protein-1
Transforming growth factor-β
Trip-1
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Summary:The human TRIP-1 (transforming growth factor-β (TGBβ)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFβ receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFβ signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5′ flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00361-5