Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after l-carnitine injection

The long-term administration of l-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of l-carnitine, the concentration of free carnitine in heart re...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 1999-01, Vol.443 (3), p.261-266
Main Authors: Kuwajima, Masamichi, Horiuchi, Masahisa, Harashima, Hideyoshi, Lu, Kang-mo, Hayashi, Miyuki, Sei, Masako, Ozaki, Kiyokazu, Kudo, Tomoko, Kamido, Hiroshi, Ono, Akira, Saheki, Takeyori, Shima, Kenji
Format: Article
Language:English
Subjects:
Aging
Animals
ANOVA, analysis of variance
Body Weight - drug effects
Cardiomegaly
Cardiomegaly - drug therapy
Cardiomegaly - metabolism
Carnitine - analogs & derivatives
Carnitine - blood
Carnitine - deficiency
Carnitine - metabolism
Carnitine - pharmacology
Carnitine acetyltransferase
Carnitine transporter
CAT, carnitine acetyltransferase
Disease Models, Animal
Half-Life
Injections, Intraperitoneal
Juvenile visceral steatosis mouse
JVS, juvenile visceral steatosis
Lipid Metabolism
Mice
Mice, Inbred Strains
Myocardium - metabolism
Organ Size - drug effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The long-term administration of l-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of l-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of l-carnitine administration in JVS mice.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)01732-3