PPARγ activators down-regulate the expression of PPARγ in 3T3-L1 adipocytes

Transcriptional activation of PPARγ by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARγ ligand, on the expression of PPARγ during and after 3T3-L1 adipocyte differentiation. Troglit...

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Bibliographic Details
Published in:FEBS letters 1999-03, Vol.447 (2), p.186-190
Main Authors: Camp, Heidi S, Whitton, Amy L, Tafuri, Sherrie R
Format: Article
Language:English
Subjects:
Anti-diabetic
Desensitization
PPAR
Troglitazone
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Summary:Transcriptional activation of PPARγ by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARγ ligand, on the expression of PPARγ during and after 3T3-L1 adipocyte differentiation. Troglitazone treatment caused a significant decrease in PPARγ proteins and DNA binding activity. This reduction was associated with a similar decrease in transcription of PPARγ mRNA. These data suggest that in 3T3-L1 cells, the expression of PPARγ is auto-regulated.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00268-9