AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis 1

Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we i...

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Bibliographic Details
Published in:FEBS letters 1999-11, Vol.462 (1-2), p.187-191
Main Authors: Page, Grit, Lödige, Inga, Kögel, Donat, Scheidtmann, Karl Heinz
Format: Article
Language:English
Subjects:
Acidic domain
Apoptosis
Dlk/ZIP kinase
Par-4
Transcription factor
Two-hybrid screen
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Summary:Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain and a putative leucine zipper characteristic of transcription factors. Indeed, a Gal4‐BD‐AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk‐induced apoptosis.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)01529-X