Simultaneous determination of medazepam and hyoscine butylbromide in tablets by second-derivative ultraviolet spectrometry

A second-derivative UV spectrophotometric method for the simultaneous determination of medazepam and hyoscine butylbromide in sugar-coated tablets without prior separation is described. In the derivative spectrophotometric determination of these drugs, calibration graphs were obtained by plotting pe...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 1998, Vol.53 (1), p.62-64
Main Authors: Karali, Nilgün, Özkirimli, Sumru, Gürsoy, Aysel
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Hyoscine butylbromide
Medazepam
Medical sciences
Pharmacology. Drug treatments
Second-derivative ultraviolet spectrometry
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Summary:A second-derivative UV spectrophotometric method for the simultaneous determination of medazepam and hyoscine butylbromide in sugar-coated tablets without prior separation is described. In the derivative spectrophotometric determination of these drugs, calibration graphs were obtained by plotting peak-trough amplitudes at 252.6 and 264.8 run versus concentration of medazepam and zero-crossing amplitude at 212.5 nm versus concentration of hyoscine butylbromide. The relative standard deviation of the method was found to be ±0.56% for medazepam and ±0.08% for hyoscine butylbromide. This method has been successfully applied to tablets containing medazepam and hyoscine butylbromide.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(97)00008-6