Simultaneous determination of guaiphenesin and codeine phosphate in tablets by high-performance liquid chromatography

A reversed-phase high-performance liquid chromatographic method has been developed for the simultaneous determination of guaiphenesin and codeine phosphate in an antitussive tablet formulation. A 10-μm C 18 column is used with a 1:1 methanol–water mixture (pH 3.0) as the mobile phase and spectrophot...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 1999-10, Vol.54 (10), p.705-709
Main Authors: Süzen, Sinan, Akay, Cemal, Cevheroğlu, Şemsettin
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Codeine phosphate
General pharmacology
Guaiphenesin
High-performance liquid chromatography
Medical sciences
Pharmacology. Drug treatments
Simultaneous determination
Tablet
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Summary:A reversed-phase high-performance liquid chromatographic method has been developed for the simultaneous determination of guaiphenesin and codeine phosphate in an antitussive tablet formulation. A 10-μm C 18 column is used with a 1:1 methanol–water mixture (pH 3.0) as the mobile phase and spectrophotometric detection is carried out at 212 nm. The total elution time is shorter than 4.4 min. The method showed good linearity, precision and reproducibility. The proposed method was successfully applied to the determination of guaiphenesin and codeine phosphate in tablets.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(99)00086-5