New palladium complexes with bis(8-thiotheophylline)alkane derivatives

• Published in: Inorganica Chimica Acta 2003-09, Vol.353, p.99-106
• Main Authors: Romerosa, Antonio, López-Magaña, Carlos, Goeta, Andrés E., Mañas, Sonia, Saoud, Mustapha, Benabdelouahab, F.B., El Guemmout, F.
• Format: Article
• Language: English
• Subjects: Bioinorganic chemistry; Metal–phosphine complexes; Metal–purine interaction; Palladium complexes; Purine derivatives
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/S0020-1693(03)00234-2

Aiming at finding new models that allow us to obtain more information about the interaction between metals and purine-biomolecules, the new derivatives bis( S-8-thiotheophylline)methane (MBTTH 2) ( 1), 1,2-bis( S-8-thiotheophylline)ethane (EBTTH 2) ( 2), 1,3-bis( S-8-thiotheophylline)propane (PBTTH 2) ( 3) and, 1,10-bis( S-8-thiotheophylline)decane (DBTTH 2) ( 4) were synthesised. The evaluation of the coordinative properties of these new ligands against cis-[PdCl 2(PPh 3) 2], leaded to the synthesis of the complexes trans-[PdCl(PPh 3) 2LH] (L=EBTT 2− ( 5), PBTT 2− ( 6)) and trans-[(PdCl(PPh 3) 2) 2L] (L=MBTT 2− ( 7), EBTT 2− ( 8), PBTT 2− ( 9), DBTT 2− ( 10)). All of the ligands and complexes were characterised by elemental analysis, IR and multinuclear ( 1H, 13C{ 1H}, 31P{ 1H} NMR) spectroscopy. The crystal structure of the ligand 1 is also presented, confirming the proposed composition for the new purine derivatives. The synthesis and characterisation of the new purine derivatives, bis( S-8-thiotheophylline)methane (MBTTH 2) ( 1), 1,2-bis( S-8-thiotheophylline)ethane (EBTTH 2) ( 2), 1,3-bis( S-8-thiotheophylline)propane (PBTTH 2) ( 3), 1,10-bis( S-8-thiotheophylline)decane (DBTTH 2) ( 4) and the complexes [PdCl(PPh 3) 2LH] (L=EBTT 2− ( 5), PBTT 2− ( 6)) and [(PdCl(PPh 3) 2) 2L] (L=MBTT 2− ( 7), EBTT 2− ( 8), PBTT 2− ( 9), DBTT 2− ( 10)), are presented. The X-ray structure of the ligand 1 is also discussed.