Plasma lipid concentrations in preeclamptic and normotensive Peruvian women

• Published in: International journal of gynecology and obstetrics 1999-12, Vol.67 (3), p.147-155
• Main Authors: Ware-Jauregui, Suzie, Sanchez, Sixto E, Zhang, Cuilin, Laraburre, Gloria, King, Irena B, Williams, Michelle A
• Format: Article
• Language: English
• Subjects: Peru; Plasma lipids; Preeclampsia; Pregnancy; Risk factors
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1016/S0020-7292(99)00161-7

Objectives: Dyslipidemia is thought to be of etiological importance in preeclampsia. We studied the relationship between maternal plasma lipid concentrations and risk of preeclampsia. Methods: A total of 125 preeclampsia cases and 179 normotensive control subjects were included in this case-control study conducted in Lima, Peru, between August 1997 and January 1998. Post-diagnosis, antepartum plasma lipid profiles were determined by standard enzymatic methods. Logistic regression procedures were used to calculate odds ratios (OR) adjusted for potential confounders. Results: Mean plasma total cholesterol and triglyceride concentrations were, on average, 6% and 21% higher in preeclamptics than controls, respectively. High-density lipoprotein (HDL) cholesterol concentrations were, on average, 9% lower in cases than controls. After adjusting for maternal age, pre-pregnancy body mass index, education, parity and other potential confounders, the risk of preeclampsia increased with successively higher quartiles of plasma triglyceride (adjusted OR: 1.00, 1.62, 2.21, 5.00, with the lowest quartile as referent; P-value for trend