Modification of Drug-Induced Catatonia and Tremors by Quipazine in Rats and Mice

Administration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations-of this drug with other antiparkinsonian agents such a...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1980, Vol.30 (2), p.129-135
Main Authors: KULKARNI, S.K., ARZI, A., KAUL, P.N.
Format: Article
Language:English
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Summary:Administration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations-of this drug with other antiparkinsonian agents such as scopolamine, diphenhydramine and amantadine were also studied in the manifestation of Parkinsonlike symptoms in the animal models. The results indicate that quipazine, a central serotonergic agent, counteracted some of the drug-induced symptoms of pseudo-parkinsonism in laboratory animals. Cholinergic, dopaminergic and histaminergic receptors play an important role in the manifestations of these symptoms.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)31481-7