The contractile effect of various agonists in the rat stomach strips

The aim of this study was to characterize the contractile effect of typical 8 agonists in rat stomach fundus strip. Sprague-Dawley rats were killed by decapitation. The stomach fundus were rapidly removed and suspended in 10-ml organ baths containg an oxygenated Krebs solution and streched with an i...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1999, Vol.79 (suppl.1), p.208-208
Main Authors: Kinbara, Shigemasa, Kawamura, Makoto, Watanabe, Mayumi, Takeda, Haruki, Araki, Tsutomu, Morinaka, Yasuhiro
Format: Article
Language:English
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Summary:The aim of this study was to characterize the contractile effect of typical 8 agonists in rat stomach fundus strip. Sprague-Dawley rats were killed by decapitation. The stomach fundus were rapidly removed and suspended in 10-ml organ baths containg an oxygenated Krebs solution and streched with an initial tension of 1 g. Changes of tension were measured isotonically with force tranducers and monitored on a polygraph. Each agonist except for cholecystokinin (CCK-8) showed a concentration-dependent contractile effect in rat stomach strips. The contractile effect of neurotensin (NT) and serotonin (5-HT) was more strongly than that of other agonists. The results indicate that NT and 5-HT can markedly elicit a contractile effect in smooth muscle cells of rat stomach. Therefore, our findings suggest that NT and 5-HT physiologically play a major role in gastric emptying.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)34847-4