Protective Effect of KW-3635, a Specific Thromboxane A2-Receptor Antagonist, on Experimental Glomerulonephritis in Mice

We studied the effect of KW-3635, a selective thromboxane A2 (TXA2)-receptor antagonist, on experimental glomerulonephritis. The glomerulonephritis was induced in mice by the administration of rabbit anti-mouse glomerular basement membrane (GBM) antibody. It was characterized as proteinuria, changes...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1994, Vol.65 (2), p.163-166
Main Authors: Kawakage, Michiyo, Sato, Kiyoshi, Karasawa, Akira
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - toxicity
Basement Membrane - immunology
Benzimidazoles - administration & dosage
Benzimidazoles - pharmacology
Benzimidazoles - therapeutic use
Benzoxepins - administration & dosage
Benzoxepins - pharmacology
Benzoxepins - therapeutic use
Biological and medical sciences
Blood Urea Nitrogen
Disease Models, Animal
Glomerulonephritis - chemically induced
Glomerulonephritis - drug therapy
Glomerulonephritis - prevention & control
Kidney Glomerulus - drug effects
Kidney Glomerulus - pathology
KW-3635
Male
Medical sciences
Mice
Nephritis
Pharmacology. Drug treatments
Proteinuria - drug therapy
Thromboxane A2 - antagonists & inhibitors
Thromboxane A2-receptor antagonist
Urinary system
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Summary:We studied the effect of KW-3635, a selective thromboxane A2 (TXA2)-receptor antagonist, on experimental glomerulonephritis. The glomerulonephritis was induced in mice by the administration of rabbit anti-mouse glomerular basement membrane (GBM) antibody. It was characterized as proteinuria, changes of serum biochemical parameters and glomerular histopathological abnormalities. The administration of KW-3635 (30 mg/kg/day, p.o.) significantly ameliorated the proteinuria, elevation of serum urea nitrogen and the thickening of GBM. These data suggest that TXA2 may play an important pathogenic role in the development and progression of glomerulonephritis.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)35775-0