Effects of Ammonia on the Gastric Mucosal Barrier in Rats and Dogs

Abstract—We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ infl...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1989, Vol.51 (1), p.143-145
Main Authors: SEIKl, Masao, MURAKAMI, Motonobu, YOO, Jung Keun, TERANUMA, Sanae, SAITA, Hiroshi, INADA, Masami, KITA, Toru, MIYAKE, Takeo
Format: Article
Language:English
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Summary:Abstract—We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ influxes into the lumen In dogs, in an exactly similar manner to rats, ammonia at concentrations of 0.1 to 0.5% increased H* loss, and ammonia at concentration of 0.5% increased both Na+ and K+ influxes into the lumen These results suggest that ammonia breaks the gastric mucosal barrier
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)40150-9