Endothelial dysfunction and an increased constriction to methoxamine in the perfused kidney in fructose-hypertensive rats

• Published in: Japanese Journal of Pharmacology 1998, Vol.76 (suppl.1), p.148-148
• Main Authors: Yamashita, Kimihito, Kamata, Katsuo
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)40702-6

Non-insulin dependent diabetes mellitus (NIDDM) is insulin-resistant and is often associated with hypertension. As one of models of insulin-resistant animals, we used the rats which had received 10% fructose in drinking water for 12 weeks. Systolic blood pressure was significantly increased in fructose-fed rats but not streptozotocin (STZ)-induced rats. Plasma levels of glucose, triglyceride, insulin and cholesterol were significantly increased in STZ-induced diabetic rats and fructose-fed rats, respectively. Acetylcholine (ACh, 10^-10 - 3×10^-6 M)-dependent vasodilatation was significantly weaker in STZ-induced diabetic rats and fructose-fed rats than in age-matched controls. SNP (10^-10 - 10^-5 M)-induced vasodilatation was not changed in STZ-induced diabetic rats and fructose-fed rats. The dose-response curve for methoxamine-induced vasoconstriction was shifted to the left, and maximum response was also increased in STZ-induced diabetic rats and fructose-fed rats. The dose-response curve for Iso (10^-10 - 10^-4 M)-induced vasodilatation was shifted to the left. These results suggest that fructose-fed rat may be useful model for insulin-resistant diabetes.