Preventive Effect of Taurine against Acute Paraquat Intoxication in Beagles

The continuous infusion of taurine markedly protected against paraquat (PQ)-induced oliguria in beagles. Pharmacokinetic studies revealed that taurine infusion increased the blood concentration of PQ and reduced the net content in the kidney and, to a lesser extent, in the lung. The excretion of PQ...

Full description

Saved in:
Bibliographic Details
Published in:Japanese Journal of Pharmacology 1989, Vol.50 (2), p.229-233
Main Authors: IZUMI, Kanji, NAGATA, Ryoichi, MOTOYA, Toshiro, YAMASHITA, Jun-ichi, HIROKANE, Taminori, NAGATA, Takahisa, SATOH, Yohji, SAWADA, Yuhsuke, ISHIBASHI, Maruo, YOSHIDA, Hiroki, FUKUDA, Takeo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dogs
Female
Infusions, Intravenous
Lung - drug effects
Lung - metabolism
Medical sciences
Paraquat - administration & dosage
Paraquat - antagonists & inhibitors
Paraquat - toxicity
Pesticides, fertilizers and other agrochemicals toxicology
Taurine - pharmacology
Toxicology
Urodynamics - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The continuous infusion of taurine markedly protected against paraquat (PQ)-induced oliguria in beagles. Pharmacokinetic studies revealed that taurine infusion increased the blood concentration of PQ and reduced the net content in the kidney and, to a lesser extent, in the lung. The excretion of PQ into the urine was unaltered. The infusion of glycine did not have such effects.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)42475-X