Effects of acidic fibroblast growth factor on hippocampal LTP in fasted rats

• Published in: Japanese Journal of Pharmacology 1992, Vol.58 (suppl.2), p.381-381
• Main Authors: Hisajima, Hiroshi, Abe, Kazuho, Nishiyama, Nobuyoshi, Saito, Hiroshi
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)49636-4

Effects of human recombinant acidic fibroblast growth factor(haFGF) on long-term potentiation (LTP) and the increase of the spike amplitude induced by weak tetanic stimulation were investigated and compared with those of CS23 (modified human basic FGF) in the dentate gyrus of 24 hr fasted and non-fasted rats. Ten μl of drug was injected into the right lateral ventricle before the application of tetanic stimulation. haFGF (400 ng) didn't influence the LTP induced by the tetanus of 100 pulses at 100 Hz in both fasted and non-fasted rats. On the other hand, the tetanus of 20 pulses at 60 Hz significantly enhanced the amplitude of population spike and facilitated the generation of LTP by the injection of 200 and 400 ng haFGF in fasted rats but not in non-fasted rats. However, 400 ng CS23 induced LTP when the tetanus of 20 pulses at 60 Hz was applied in both fasted and non-fasted states. These results suggest that haFGF might be one of regulating factors of feeding and memory.