Effect of NaF on the Small Intestinal Transit of Mice

• Published in: Japanese Journal of Pharmacology 1994, Vol.64 (suppl.2), p.290-290
• Main Authors: Hamada, Setsuo, Akiyama, Yukiko, Hashimoto, Rika, Kawasaki, Tohru
• Format: Article
• Language: eng ; jpn
• ISSN: 0021-5198
• DOI: 10.1016/S0021-5198(19)50792-2

The effect of NaF on the small intestinal transit of a charcoal suspension was examined in mice. The mice were given 0.1ml/20g of an aqueous suspension of 2% charcoal containing 2% gum arabic by an oral sonde needle. Twenty min later, the mice were killed by cervical dislocation, and the stomach and intestines were excised from the gastroesophageal junction to the ileocecal junction. The NaF solution was dissolved in the charcoal suspension. The intestinal transit percent in the control (0.9% NaCl) group was 58.1%. The intestinal transit percent in the 0.1, 0.2, 1, 5 and 10% NaF groups was 52.5%, 62.4%, 86.4%, 98.3% and 94.3% respectively. There was no significant difference in intestinal transit between the 0.1 or 0.2% NaF groups and control group. However, intestinal transit was significantly promoted by 1, 5 and 10% NaF compared to the control. The intestinal transit of morphine (10mg/kg, s.c.) and 5% NaF in combination was more rapid than that of morphine alone.