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Effect of low selenium diet on streptozotocin-induced diabetic rats
We studied the effect of a low selenium diet on streptozotocin-induced diabetic rats. Male Wistar rats, weighing 30 to 40 g at the beginning of the experiment, immediately after weaning were provided with a low selenium diet consisting of a basic ration, including 0.0027% selenium, for 4 weeks. Stre...
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Published in: | Japanese Journal of Pharmacology 1994, Vol.64 (suppl.2), p.343-343 |
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Main Authors: | , , , |
Format: | Article |
Language: | eng ; jpn |
Online Access: | Get full text |
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Summary: | We studied the effect of a low selenium diet on streptozotocin-induced diabetic rats. Male Wistar rats, weighing 30 to 40 g at the beginning of the experiment, immediately after weaning were provided with a low selenium diet consisting of a basic ration, including 0.0027% selenium, for 4 weeks. Streptozotocin (75 mg/kg) was intraperitoneally injected at 4 weeks after breeding, and these rats were continuously maintained on the low selenium diet for 4 weeks. Control rats were provided with a basic diet for 4 weeks, streptozotocin was shnilary injected, and a basic ration was continuously given for 4 weeks. Serum samples were collected at 4 weeks after injection of streptozotocin and the liver was quickly removed. There was no srgmficant difference in levels of glucose, lipidperoxide and superoxid disumutase (SOD) activity in the serum and liver in rats maintained on the basic or low selenium diets. Although the glucose, lipidperoxide and SOD levels in the serum and liver were significantly increased by the injection of streptozotocin, these levels in the serum and liver in rats maintained on the low selenium diet were significantly higher than those in rats maintainea on a basic diret. These results suggested that a selenium- deficient state will aggravate diabetes mellitus. |
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ISSN: | 0021-5198 |
DOI: | 10.1016/S0021-5198(19)51004-6 |