Transient resensitization of guinea-pig smooth muscle during the development of carbachol-induced heterologous desensitization to histamine

Development of homologous desensitization to carbachol is intervened with a transient resensitization in guinea-pig taenia caeci in the presence of extracellular Ca. A similar procedure for producing carbachol-induced desensitization caused a reduction in contractility of the muscle in response to h...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1993, Vol.61 (suppl.1), p.260-260
Main Authors: Sato, Ryo, Hishinuma, Shigeru, Matsumoto, Yukio, Uchida, Masaatsu K., Kurokawa, Masanori
Format: Article
Language:eng ; jpn
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Summary:Development of homologous desensitization to carbachol is intervened with a transient resensitization in guinea-pig taenia caeci in the presence of extracellular Ca. A similar procedure for producing carbachol-induced desensitization caused a reduction in contractility of the muscle in response to histamine. We investigated whether the carbachol-induced heterologous desensitization to histamine was also intervened with a transient resensitization. Contraction in response to histamine in the presence of Ca was transiently resensitized during carbachol-induced desensitization. On the other hand, the histamine-elicited contraction in the absence of Ca was desensitized only gradually without any transient resensitization. We therefore conclude that the transient resensitization occurs only in contraction caused by influx of extracellular Ca , irrespective of the species of agonists.
ISSN:0021-5198
DOI:10.1016/S0021-5198(19)51906-0