Immunopharmacologic Profiles of a Thiol Protease Inhibitor, L-Trans-Dicyclohexyl Epoxysuccinate

Ep-1, L-trans-Dicyclohexyl epoxysuccinate, is a synthetic and specific inhibitor of thiol proteases. The effects of this inhibitor on some immunological parameters were examined in normal and immunity-impaired mice and rats. In the cultures of splenocytes obtained from the mice treated with Ep-1, it...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1984, Vol.34 (3), p.336-343
Main Authors: AMAMOTO, Toshiro, OKAZAKI, Tadayasu, KOMURASAKI, Toshi, OGUMA, Kiyoshi, TAMAI, Masaharu, HANADA, Kazunori, OMURA, Sadafumi
Format: Article
Language:English
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Summary:Ep-1, L-trans-Dicyclohexyl epoxysuccinate, is a synthetic and specific inhibitor of thiol proteases. The effects of this inhibitor on some immunological parameters were examined in normal and immunity-impaired mice and rats. In the cultures of splenocytes obtained from the mice treated with Ep-1, it enhanced the lymphocyte blast transformation induced by both suboptimal and optimal concentrations of concanavalin A (Con A) and Lens culinaris (LC). The in vivo administration of Ep-1 caused a depression of the plaque forming cells (PFC) for sheep red blood cell (SRBC) and enhanced the delayed-type hypersensitivity (DTH) for bovine serum albumin (BSA) as well as mixed lymphocytes cultures (MLC). Furthermore, Ep-1 demonstrated a preventive effect on adjuvant arthritic rats. The relevance of immunological regulation and the mode of action of Ep-1 as a thiol protease inhibitor are discussed in these findings.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)52323-X