Ameliorative effects of RS-8359 on cerebrovascular disorders

• Published in: Japanese Journal of Pharmacology 1989, Vol.49 (suppl), p.233-233
• Main Authors: Kozuka, Masao, Kobayashi, Kazuo, Tonohiro, Toshiyuki, Yokoyama, Tomihisa, Kubo, Yoshiko, Iwata, Nobuyoshi
• Format: Article
• Language: eng ; jpn
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)56534-9

RS-8359, a new reversible type-A monoamineoxidase (MAO) inhibitor, prevented the decrease in noradrenaline (30 mg/kg, po) and improved the delayed hypoperfusion (10 mg/kg, po) induced by 30 min 4-vessel occlusion followed by 1 hr reperfusion in rats. RS-8359 ameliorated the lowered erythrocyte deformability and the increased blood viscosity induced by bilateral carotid artery occlusion (BCAO) in rats. These improvements in rheology might be caused by an action of this compound other than MAO inhibition. RS-8359 protected the hippocampal CAl neuron from delayed neuronal death induced by a transient ischemia in gerbils (30 mg/kg×2/day, 3.5 day, po), and prevented the decrease in ATP by BCAO in spontaneously hypertensive rats (30 mg/kg, po). RS-8359 (10 mg/kg, id) normalized both the elevated slow (δ) wave activity and the decreased fast (α) wave activity of electrocorticogram induced by electrical lesion of the bilateral internal capsule in cats. These results suggest the possibility of RS-8359 as a beneficial drug against stroke.