The endothelium-derived vasoconstrictor peptide endothelin inhibits renin release from rat kidney cortical slices

• Published in: Japanese Journal of Pharmacology 1989, Vol.49 (suppl), p.293-293
• Main Authors: Matsumura, Yasuo, Nakase, Kohji, Ikegawa, Ruriko, Hayashi, Kazutaka, Ohyama, Tadashi, Morimoto, Shiro
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)56715-4

The effect of endothelin, a newly identified endothelium-derived vasoconstrictor peptider, on renin release from rat kidney cortical slices was examined. Endothelin produced a concentration-dependent inhibition of renin release and this inhibitory effect was dependent on extracellular calcium. The dihydropyridine calcium channel blockers nifedipine and nicardipine did not antagonize the inhibitory effect induced by endo-thelin. On the other hand, nifedipine completely antagonized the extra-cellular high potassium-or Bay K 8644-induced inhibition of rennin release. The endothelin-induced inhibition of the release was markedly blocked by the addition of Co2+ . Similar blocking effects of Co2+ were also observed with extracellular high potassium or Bay K 8644. Thus, endothelin exerts an inhibitory action on renin release in vitro, in a calcium-dependent manner. This inhibition may be mediated by the increased calcium influx through dihydropyridine-insensitive calcium channels.