Inhibitory effect of “TJ-960” on cobalt-induced epilepsy in rats

The Japanese Kampo prescription “TJ-960”, a mixture of nine herbal drugs , shows excellent effects on refractory epileptics, who have long been unsuccessfully treated with various established anticonvulsant drugs . Experimental cobalt-induced epilepsy is well known as a human cortical epileptic mode...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1988, Vol.46 (suppl), p.240-240
Main Authors: Sekiguchi, Kyoji, Ishige, Atsushi, Yuzurihara, Mitsutoshi, Iizuka, Susumu, Itoh, Kouichi, Sugimoto, Akira, Aburada, Masaki, Hosoya, Eikichi, Sugaya, Eiichi
Format: Article
Language:English
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Summary:The Japanese Kampo prescription “TJ-960”, a mixture of nine herbal drugs , shows excellent effects on refractory epileptics, who have long been unsuccessfully treated with various established anticonvulsant drugs . Experimental cobalt-induced epilepsy is well known as a human cortical epileptic model. To elucidate the mechanism of anticonvulsant action of TJ-960, the effect of TJ-960 on cobalt-induced EEG changes were examined. Male wistar rats were used. Cobalt powder was applied on the cortex of the left frontal lobe. The EEG was recorded 6 hours every day for 20 days after application of cobalt. EEG showed seizure patterns after application of cobalt. Although anticonvulsants such as phenytoin, ethosuximide and sodium valproate showed no inhibitory effect on the abnormal EEG changes induced by cobalt, such abnormal changes in EEG were inhibited b TJ-960.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)57562-X