Cyclic AMP potentiates the retinoic acid-induced expression of tissue transglutaminase in peritoneal macrophages

Fresh serum and retinoids induce the expression of tissue transglutaminase in cultured mouse resident peritoneal macrophages. Analogues of cyclic AMP, such as dibutyryl cyclic AMP, and agents that increase intracellular cyclic AMP levels enhance the induction. Dibutyryl cyclic AMP alone has little e...

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Bibliographic Details
Published in:The Journal of biological chemistry 1986-01, Vol.261 (2), p.614-621
Main Authors: Murtaugh, M P, Moore, W T, Davies, P J
Format: Article
Language:English
Subjects:
Animals
Ascitic Fluid
Biological and medical sciences
Blood
Bucladesine - pharmacology
Butyrates - pharmacology
Butyric Acid
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cyclic AMP - pharmacology
Dibutyryl Cyclic GMP - pharmacology
Drug Synergism
Enzyme Induction
Fundamental and applied biological sciences. Psychology
Kinetics
Macrophages - drug effects
Macrophages - enzymology
Male
Mice
Molecular and cellular biology
Retinol-Binding Proteins - metabolism
Transglutaminases - biosynthesis
Tretinoin - pharmacology
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Summary:Fresh serum and retinoids induce the expression of tissue transglutaminase in cultured mouse resident peritoneal macrophages. Analogues of cyclic AMP, such as dibutyryl cyclic AMP, and agents that increase intracellular cyclic AMP levels enhance the induction. Dibutyryl cyclic AMP alone has little effect on transglutaminase expression, but it increases the sensitivity of macrophages to low concentrations of either serum or retinoic acid. Dibutyryl cyclic AMP potentiates the transglutaminase-inducing activity of both free retinoic acid and retinoic acid bound to the serum retinol-binding protein. Pretreating macrophages with dibutyryl cyclic AMP or retinoic acid does not prime the cells to respond to the other agent; instead, both agents must be present simultaneously to obtain the synergistic induction of transglutaminase. Our studies suggest that the modulation of intracellular cyclic AMP levels may have pronounced effects on retinoic acid-induced gene expression in myeloid cells.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(17)36136-7