Polymorphism of Rhesus Monkey Serum Prealbumin

Two genetic variants of Rhesus monkey prealbumin, Pt 1-1 and Pt 2-2, have been purified by ion exchange chromatography followed by preparative polyacrylamide gel electrophoresis. Both monkey proteins have molecular weights of approximately 54,000 as determined by ultracentrifugation. Amino acid comp...

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Bibliographic Details
Published in:The Journal of biological chemistry 1973-11, Vol.248 (22), p.7898-7903
Main Authors: van Jaarsveld, Pieter, Branch, William T., Robbins, Jacob, Morgan, Francis J., Kanda, Yoshikazu, Canfield, Robert E.
Format: Article
Language:English
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Summary:Two genetic variants of Rhesus monkey prealbumin, Pt 1-1 and Pt 2-2, have been purified by ion exchange chromatography followed by preparative polyacrylamide gel electrophoresis. Both monkey proteins have molecular weights of approximately 54,000 as determined by ultracentrifugation. Amino acid compositions of both variants are very similar. Peptide maps of the two monkey prealbumins differ definitely from each other in only one peptide. The NH2-terminal sequences (1 to 21) suggest that each variant of Rhesus prealbumin is composed of identical subunits; an interchange of valine and isoleucine is found at residue 5 in Rhesus prealbumin. The structural features of both Rhesus prealbumins are very similar to those of human prealbumin.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)43274-2